Assay Detail
Binding
CHEMBL5229426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level in presence of IDX medium by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BMMSC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of <i>Orixa japonica</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.33 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.70 |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | 5.64 |
| CHEMBL5268127 | — | — | 1 | 4.86 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.11 |
| CHEMBL2071526 | ALTISSIMACOUMARIN D | — | 1 | - |
| CHEMBL307341 | AURAPTENE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL472 | GLYBURIDE | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5268127 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL165 | RESVERATROL | EC50 | = | 77100.0 | nM | 4.11 |
| CHEMBL2071526 | ALTISSIMACOUMARIN D | EC50 | > | 30000.0 | nM | - |
| CHEMBL307341 | AURAPTENE | EC50 | > | 30000.0 | nM | - |