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Assay Detail

CHEMBL5229463

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, Optical Properties, and Antiproliferative Evaluation of NBD-Triterpene Fluorescent Probes.
Medina-O'Donnell M, Vega-Granados K, Martinez A, Sepúlveda MR, Molina-Bolívar JA, Álvarez de Cienfuegos L, Parra A, Reyes-Zurita FJ, Rivas F.
J Nat Prod (2023) 86 : 166 -175
PubMed 36542806 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.49 5.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5273267 1 5.18
CHEMBL201820 BENZYL MASLINATE 1 4.82
CHEMBL5270287 1 4.71
CHEMBL201515 MASLINIC ACID 1 4.49
CHEMBL5275433 1 4.34
CHEMBL5265897 1 4.20
CHEMBL445301 1 4.17
CHEMBL5278898 1 4.02
CHEMBL168 OLEANOLIC_ACID 1 -
CHEMBL5274659 1 -
CHEMBL5288968 1 -
CHEMBL5280267 1 -
CHEMBL5286591 1 -
CHEMBL5273450 1 -
CHEMBL5267678 1 -
CHEMBL5289482 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5273267 IC50 = 6600.0 nM 5.18
CHEMBL201820 BENZYL MASLINATE IC50 = 15300.0 nM 4.82
CHEMBL5270287 IC50 = 19500.0 nM 4.71
CHEMBL201515 MASLINIC ACID IC50 = 32200.0 nM 4.49
CHEMBL5275433 IC50 = 45200.0 nM 4.34
CHEMBL5265897 IC50 = 63300.0 nM 4.20
CHEMBL445301 IC50 = 67100.0 nM 4.17
CHEMBL5278898 IC50 = 95900.0 nM 4.02
CHEMBL168 OLEANOLIC_ACID IC50 = 429900.0 nM -
CHEMBL5274659 IC50 = 120700.0 nM -
CHEMBL5288968 IC50 = 105400.0 nM -
CHEMBL5280267 IC50 = 122800.0 nM -
CHEMBL5286591 IC50 = 113000.0 nM -
CHEMBL5273450 IC50 = 109800.0 nM -
CHEMBL5267678 IC50 = 100900.0 nM -
CHEMBL5289482 IC50 = 108300.0 nM -