Assay Detail
Binding
CHEMBL5229528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of OCT1(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT1 using ASP+ as substrate incubated for 5 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.54 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861111 | — | — | 1 | 5.46 |
| CHEMBL5280198 | — | — | 1 | 4.95 |
| CHEMBL1790041 | RANITIDINE | 4.0 | 1 | 4.55 |
| CHEMBL3613729 | — | — | 1 | 4.45 |
| CHEMBL97453 | WEDELOLACTONE | — | 1 | 4.42 |
| CHEMBL28 | APIGENIN | — | 1 | 4.41 |
| CHEMBL5266270 | — | — | 1 | 4.40 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 4.40 |
| CHEMBL5266163 | — | — | 1 | 4.38 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.34 |
| CHEMBL356036 | TETRAMETHYLKAEMPFEROL | — | 1 | 4.33 |
| CHEMBL5285127 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861111 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL5280198 | — | IC50 | = | 11180.0 | nM | 4.95 |
| CHEMBL1790041 | RANITIDINE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3613729 | — | IC50 | = | 35180.0 | nM | 4.45 |
| CHEMBL97453 | WEDELOLACTONE | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL28 | APIGENIN | IC50 | = | 38880.0 | nM | 4.41 |
| CHEMBL5266270 | — | IC50 | = | 40150.0 | nM | 4.40 |
| CHEMBL660 | AMANTADINE | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL5266163 | — | IC50 | = | 41280.0 | nM | 4.38 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 46080.0 | nM | 4.34 |
| CHEMBL356036 | TETRAMETHYLKAEMPFEROL | IC50 | = | 46960.0 | nM | 4.33 |
| CHEMBL5285127 | — | IC50 | = | 47310.0 | nM | 4.33 |