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Assay Detail

CHEMBL5229566

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human YAPC cells assessed as inhibition of cell growth by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type YAPC
Confidence 1 — Organism
Curated By Autocuration

Target

YAPC (CHEMBL612815)
Type CELL-LINE
Organism Homo sapiens

Publication

Dichapetalins from the Twigs of <i>Dichapetalum longipetalum</i> with Cytotoxic Activities.
Zhou B, Gao XH, Zhang MM, Liu HC, Yue JM.
J Nat Prod (2023) 86 : 209 -221
PubMed 36583957 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.84 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE 4.0 1 6.51
CHEMBL5279667 1 5.17
CHEMBL5290327 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE IC50 = 310.0 nM 6.51
CHEMBL5279667 IC50 = 6700.0 nM 5.17
CHEMBL5290327 IC50 > 10000.0 nM -