Assay Detail
Functional
CHEMBL5229865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 FFM7/MT358643 infected in human Calu-3 cells assessed as inhibition of viral replication incubated for 48 hrs by immunohistochemistry analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Calu-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.46 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 8.90 |
| CHEMBL204813 | SANGGENON C | — | 1 | 5.34 |
| CHEMBL5281602 | — | — | 1 | 5.12 |
| CHEMBL525084 | SANGGENON O | — | 1 | 5.10 |
| CHEMBL5269476 | — | — | 1 | 4.73 |
| CHEMBL464006 | MORUSIN | — | 1 | 4.60 |
| CHEMBL1770312 | KUWANON A | — | 1 | 4.45 |
| CHEMBL377937 | KUWANON L | — | 1 | - |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL204813 | SANGGENON C | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5281602 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL525084 | SANGGENON O | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5269476 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL464006 | MORUSIN | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL1770312 | KUWANON A | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL377937 | KUWANON L | IC50 | > | 20000.0 | nM | - |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | > | 100000.0 | nM | - |