Assay Detail
Functional
CHEMBL5229952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity in C57BL/6J mouse primary neocortical neurons assessed as inhibition of 4-AP-induced spontaneous Ca2+ oscillation frequency treated with compound 15 mins prior to 4-AP challenge and measured after 10 mins by Fluo-4 dye based fluorescence analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Primary neocortical neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A Drimane Meroterpenoid Borate as a Synchronous Ca<sup>+</sup> Oscillation Inhibitor from the Coral-Associated Fungus <i>Alternaria</i> sp. ZH-15.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.89 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279954 | — | — | 1 | 4.92 |
| CHEMBL24686 | TERRITREM B | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279954 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL24686 | TERRITREM B | IC50 | = | 14000.0 | nM | 4.85 |