Assay Detail
Functional
CHEMBL5230044
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Antiinflammatory activity in human 293/NFkB-Luc cells assessed as inhibition of TNF-alpha induced NFkaapaB activity preincubated for 15 mins followed by TNF-alpha induction and measured after 6 hrs by luminescence based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 293/NFkB-luc |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anti-inflammatory Quinoline Alkaloids from the Roots of <i>Waltheria indica</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.02 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3105822 | — | — | 1 | 5.15 |
| CHEMBL5274355 | — | — | 1 | 5.14 |
| CHEMBL5288852 | — | — | 1 | 5.05 |
| CHEMBL403183 | — | — | 1 | 5.01 |
| CHEMBL5288691 | — | — | 1 | 5.00 |
| CHEMBL5291228 | — | — | 1 | 4.99 |
| CHEMBL5267196 | — | — | 1 | 4.99 |
| CHEMBL3342751 | — | — | 1 | 4.92 |
| CHEMBL5272581 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3105822 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5274355 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5288852 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL403183 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5288691 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5291228 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5267196 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3342751 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL5272581 | — | IC50 | = | 11900.0 | nM | 4.92 |