Assay Detail
Binding
CHEMBL5230436
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Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence based analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.91 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279656 | — | — | 1 | 9.36 |
| CHEMBL5281591 | — | — | 1 | 9.00 |
| CHEMBL5277567 | — | — | 1 | 7.00 |
| CHEMBL5270233 | — | — | 1 | 6.70 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 6.14 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.95 |
| CHEMBL398940 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279656 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL5281591 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5277567 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5270233 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL398940 | — | IC50 | = | 57000.0 | nM | 4.24 |