Assay Detail
Binding
CHEMBL5230437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells at 50 uM by SPR analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Spike glycoprotein (CHEMBL4662936) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.20 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216826 | — | — | 1 | 6.22 |
| CHEMBL1214598 | UMIFENOVIR | 3.0 | 1 | 5.39 |
| CHEMBL5277868 | — | — | 1 | 5.35 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.97 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216826 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1214598 | UMIFENOVIR | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL5277868 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL50 | QUERCETIN | IC50 | = | 83400.0 | nM | 4.08 |