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Assay Detail

CHEMBL5230444

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human wild type full length ACE2 peptide assessed as inhibition
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Angiotensin-converting enzyme 2 (CHEMBL3736)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.
Xiu S, Dick A, Ju H, Mirzaie S, Abdi F, Cocklin S, Zhan P, Liu X.
J Med Chem (2020) 63 : 12256 -12274
PubMed 32539378 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.76 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5274408 1 5.22
CHEMBL5284169 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5274408 IC50 = 6000.0 nM 5.22
CHEMBL5284169 IC50 = 50000.0 nM 4.30