Assay Detail
Functional
CHEMBL5230445
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Antiviral activity against pseudovirus SARS-CoV spike protein infected in HeLa cells over expressing ACE2 assessed as inhibition on pseudovirus infection incubated for 52 hrs by luminescence based microplate reader analysis
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.07 | 7.00 |
| IC50 | 2 | 6.85 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284169 | — | — | 1 | 7.00 |
| CHEMBL423112 | — | — | 1 | 7.00 |
| CHEMBL5274408 | — | — | 1 | 6.70 |
| CHEMBL263634 | — | — | 1 | 6.56 |
| CHEMBL5278408 | — | — | 1 | 5.52 |
| CHEMBL401925 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284169 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL423112 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5274408 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL263634 | — | EC50 | = | 273.0 | nM | 6.56 |
| CHEMBL5278408 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL401925 | — | EC50 | = | 6400.0 | nM | 5.19 |