Assay Detail

CHEMBL5230455

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HCoV-NL63 assessed as viral growth inhibition

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human coronavirus NL63
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.

Xiu S, Dick A, Ju H, Mirzaie S, Abdi F, Cocklin S, Zhan P, Liu X.
J Med Chem (2020) 63 : 12256 -12274
PubMed 32539378 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.70	8.17

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL91704	K-777	2.0	1	8.17
CHEMBL5283406	—	—	1	5.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL91704	K-777	IC50	=	6.78	nM	8.17
CHEMBL5283406	—	IC50	=	6020.0	nM	5.22