Assay Detail
Binding
CHEMBL5230554
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Inhibition of human Keap1-Nrf2 protein-protein interaction by ELISA method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.52 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.78 |
| CHEMBL1200969 | DUTASTERIDE | 4.0 | 1 | 5.55 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL1200969 | DUTASTERIDE | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 5870.0 | nM | 5.23 |