Assay Detail
Binding
CHEMBL5230561
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Inhibition of human Keap1-Nrf2 protein-protein interaction by fluorescence polarization assay
17
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.47 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160447 | — | — | 1 | 8.00 |
| CHEMBL4858288 | — | — | 1 | 7.84 |
| CHEMBL4169002 | — | — | 1 | 7.51 |
| CHEMBL3632711 | — | — | 1 | 7.20 |
| CHEMBL5277720 | — | — | 1 | 7.20 |
| CHEMBL3928693 | — | — | 1 | 6.94 |
| CHEMBL5285536 | — | — | 1 | 6.82 |
| CHEMBL3617787 | — | — | 2 | 6.71 |
| CHEMBL5273301 | — | — | 1 | 6.70 |
| CHEMBL1969108 | — | — | 1 | 6.59 |
| CHEMBL4648717 | — | — | 1 | 5.60 |
| CHEMBL4208450 | — | — | 1 | 5.57 |
| CHEMBL5273569 | — | — | 2 | 4.00 |
| CHEMBL5275624 | — | — | 2 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160447 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4858288 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4169002 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3632711 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5277720 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3928693 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5285536 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3617787 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5273301 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1969108 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL3617787 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL4648717 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4208450 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5275624 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5273569 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5275624 | — | IC50 | = | 185200.0 | nM | - |
| CHEMBL5273569 | — | IC50 | = | 185200.0 | nM | - |