Assay Detail
Binding
CHEMBL5230588
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PFKFB3 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (CHEMBL2331053) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PFKFB3 inhibitors as potential anticancer agents: Mechanisms of action, current developments, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.95 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155103 | — | — | 1 | 6.74 |
| CHEMBL3105836 | — | — | 1 | 6.68 |
| CHEMBL242739 | — | — | 1 | 6.17 |
| CHEMBL234338 | — | — | 1 | 5.53 |
| CHEMBL3105848 | — | — | 1 | 4.64 |
| CHEMBL4751366 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155103 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3105836 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL242739 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL234338 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL3105848 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL4751366 | — | IC50 | = | 2000000.0 | nM | - |