Assay Detail
Binding
CHEMBL5230596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PFKFB3 (unknown origin) incubated for 90 mins by ADP-Glo luminescent assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (CHEMBL2331053) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PFKFB3 inhibitors as potential anticancer agents: Mechanisms of action, current developments, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.37 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5078139 | — | — | 1 | 8.46 |
| CHEMBL5273875 | — | — | 1 | 8.38 |
| CHEMBL5076616 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5078139 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5273875 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5076616 | — | IC50 | = | 5.2 | nM | 8.28 |