Assay Detail
Binding
CHEMBL5230682
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Inhibition of c-Src (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of Wee1 inhibitors: A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.54 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181285 | — | — | 1 | 8.40 |
| CHEMBL178758 | — | — | 1 | 7.89 |
| CHEMBL359898 | — | — | 1 | 7.85 |
| CHEMBL181095 | — | — | 1 | 7.64 |
| CHEMBL301612 | — | — | 1 | 7.62 |
| CHEMBL113070 | — | — | 1 | 7.50 |
| CHEMBL366922 | — | — | 1 | 7.00 |
| CHEMBL180821 | — | — | 1 | 6.44 |
| CHEMBL181017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181285 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL178758 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL359898 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL181095 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL301612 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL113070 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL366922 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL180821 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL181017 | — | IC50 | > | 50000.0 | nM | - |