Assay Detail
Binding
CHEMBL5230716
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Inhibition of CDK1 (unknown origin)
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A comprehensive insight on the recent development of Cyclic Dependent Kinase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.82 | 8.52 |
| Ki | 1 | 8.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384304 | RG-547 | 2.0 | 1 | 8.70 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 8.52 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 8.00 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 7.80 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.70 |
| CHEMBL3991935 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384304 | RG-547 | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL445813 | AT-7519 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3991935 | — | IC50 | = | 79.0 | nM | 7.10 |