Assay Detail
Binding
CHEMBL5230717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2 (unknown origin)
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A comprehensive insight on the recent development of Cyclic Dependent Kinase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.90 | 9.00 |
| Ki | 1 | 8.52 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 9.00 |
| CHEMBL384304 | RG-547 | 2.0 | 1 | 8.52 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 8.22 |
| CHEMBL1230607 | PHA-793887 | 1.0 | 1 | 8.10 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 8.00 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.70 |
| CHEMBL564829 | MILCICLIB | 2.0 | 1 | 7.35 |
| CHEMBL5273925 | — | — | 1 | 7.32 |
| CHEMBL5285495 | — | — | 1 | 6.80 |
| CHEMBL5269468 | — | — | 1 | 6.52 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.16 |
| CHEMBL5280632 | — | — | 1 | 5.43 |
| CHEMBL5275225 | — | — | 1 | 5.35 |
| CHEMBL5280858 | — | — | 1 | 5.33 |
| CHEMBL5281901 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL384304 | RG-547 | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1230607 | PHA-793887 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL445813 | AT-7519 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL564829 | MILCICLIB | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5273925 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5285495 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5269468 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5280632 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5275225 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5280858 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL5281901 | — | IC50 | = | 5200.0 | nM | 5.28 |