Assay Detail

CHEMBL5230725

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Binding

Inhibition of CDK8 (unknown origin)

ChEMBL ↗

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Target

Cyclin-dependent kinase 8 (CHEMBL5719) ↗

Open DB target context

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Cyclin-dependent kinase 8 (CHEMBL5719) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cyclin-dependent kinase 8

CHEMBL5719

Anchored from Assay target.

Protein identity Cyclin-dependent kinase 8

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cyclin-dependent kinase 8 (CHEMBL5719) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

A comprehensive insight on the recent development of Cyclic Dependent Kinase inhibitors as anticancer agents.

Marak BN, Dowarah J, Khiangte L, Singh VP.
Eur J Med Chem (2020) 203 : 112571 -112571
PubMed 32707525 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.36	8.36

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4225966	SEL-120 FREE BASE	1.0	1	8.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4225966	SEL-120 FREE BASE	IC50	=	4.4	nM	8.36