Assay Detail
Binding
CHEMBL5230802
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Inhibition of Escherichia coli metallo-beta-lactamase NDM-1 assessed as substrate hydrolysis using cefazolin as substrate preincubated for 12 hrs followed by substrate by UV-Vis spectrophotometric analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design of covalent inhibitors targeting metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.59 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177837 | BROMOPYRUVATE | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177837 | BROMOPYRUVATE | IC50 | = | 2570.0 | nM | 5.59 |