Assay Detail
Binding
CHEMBL5230804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of metallo-beta-lactamase IMP-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as substrate hydrolysis using imipenem as substrate by spectrometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design of covalent inhibitors targeting metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.99 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333177 | — | — | 1 | 6.28 |
| CHEMBL5290744 | — | — | 1 | 6.24 |
| CHEMBL121516 | BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE | — | 1 | 6.06 |
| CHEMBL583959 | BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE | — | 1 | 6.02 |
| CHEMBL120082 | BIS(DIBENZYLAMINETHIOCARBONYL)DISULFIDE | — | 1 | 5.77 |
| CHEMBL964 | DISULFIRAM | 4.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333177 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5290744 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL121516 | BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL583959 | BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL120082 | BIS(DIBENZYLAMINETHIOCARBONYL)DISULFIDE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL964 | DISULFIRAM | IC50 | = | 2900.0 | nM | 5.54 |