Assay Detail
Functional
CHEMBL5230856
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.63 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282557 | — | — | 1 | 5.88 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.52 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282557 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 3330.0 | nM | 5.48 |