Assay Detail
Functional
CHEMBL5230867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.55 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279000 | — | — | 1 | 4.90 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.61 |
| CHEMBL418068 | RHEIN | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279000 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL939 | GEFITINIB | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL418068 | RHEIN | IC50 | = | 71500.0 | nM | 4.15 |