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Assay Detail

CHEMBL5230945

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Hydroxamic acid hybrids as the potential anticancer agents: An Overview.
Liu W, Liang Y, Si X.
Eur J Med Chem (2020) 205 : 112679 -112679
PubMed 32791404 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.82 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5270399 1 7.75
CHEMBL5274330 1 6.21
CHEMBL5265820 1 6.21
CHEMBL5286862 1 6.21
CHEMBL5277805 1 6.21
CHEMBL5272141 1 6.06
CHEMBL3342182 1 6.06
CHEMBL5271817 1 6.06
CHEMBL5268365 1 6.06
CHEMBL3342181 1 6.06
CHEMBL98 VORINOSTAT 4.0 1 6.05
CHEMBL5269679 1 5.48
CHEMBL5275684 1 5.48
CHEMBL5266050 1 5.31
CHEMBL5275305 1 5.31
CHEMBL5273409 1 5.31
CHEMBL5282167 1 5.31
CHEMBL5268663 1 5.14
CHEMBL23293 SALIRASIB 2.0 1 4.31
CHEMBL5275537 1 -
CHEMBL5270559 1 -
CHEMBL5273944 1 -
CHEMBL5283925 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5270399 IC50 = 18.0 nM 7.75
CHEMBL5274330 IC50 = 620.0 nM 6.21
CHEMBL5265820 IC50 = 620.0 nM 6.21
CHEMBL5286862 IC50 = 620.0 nM 6.21
CHEMBL5277805 IC50 = 620.0 nM 6.21
CHEMBL5272141 IC50 = 880.0 nM 6.06
CHEMBL3342182 IC50 = 880.0 nM 6.06
CHEMBL5271817 IC50 = 880.0 nM 6.06
CHEMBL5268365 IC50 = 880.0 nM 6.06
CHEMBL3342181 IC50 = 880.0 nM 6.06
CHEMBL98 VORINOSTAT IC50 = 900.0 nM 6.05
CHEMBL5269679 IC50 = 3320.0 nM 5.48
CHEMBL5275684 IC50 = 3320.0 nM 5.48
CHEMBL5266050 IC50 = 4860.0 nM 5.31
CHEMBL5275305 IC50 = 4860.0 nM 5.31
CHEMBL5273409 IC50 = 4930.0 nM 5.31
CHEMBL5282167 IC50 = 4930.0 nM 5.31
CHEMBL5268663 IC50 = 7190.0 nM 5.14
CHEMBL23293 SALIRASIB IC50 = 48600.0 nM 4.31
CHEMBL5275537 IC50 = 1.28 ug.mL-1 -
CHEMBL5270559 IC50 = 1.28 ug.mL-1 -
CHEMBL5273944 IC50 = 1.28 ug.mL-1 -
CHEMBL5283925 IC50 = 1.28 ug.mL-1 -