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Assay Detail

CHEMBL5230959

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Functional
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Hydroxamic acid hybrids as the potential anticancer agents: An Overview.
Liu W, Liang Y, Si X.
Eur J Med Chem (2020) 205 : 112679 -112679
PubMed 32791404 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.62 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98 VORINOSTAT 4.0 2 6.75
CHEMBL5287395 1 6.22
CHEMBL5265820 1 6.21
CHEMBL5286862 1 6.21
CHEMBL5277805 1 6.21
CHEMBL4533956 1 5.80
CHEMBL5275684 1 5.48
CHEMBL5269679 1 5.48
CHEMBL5273409 1 5.31
CHEMBL5275305 1 5.31
CHEMBL5266050 1 5.31
CHEMBL5282167 1 5.31
CHEMBL5276607 1 4.73
CHEMBL23293 SALIRASIB 2.0 1 4.31
CHEMBL29292 UBENIMEX 2.0 1 -
CHEMBL5275537 1 -
CHEMBL5270559 1 -
CHEMBL5273944 1 -
CHEMBL5283925 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98 VORINOSTAT IC50 = 180.0 nM 6.75
CHEMBL5287395 IC50 = 600.0 nM 6.22
CHEMBL5265820 IC50 = 620.0 nM 6.21
CHEMBL5286862 IC50 = 620.0 nM 6.21
CHEMBL5277805 IC50 = 620.0 nM 6.21
CHEMBL4533956 IC50 = 1600.0 nM 5.80
CHEMBL5275684 IC50 = 3320.0 nM 5.48
CHEMBL5269679 IC50 = 3320.0 nM 5.48
CHEMBL5275305 IC50 = 4860.0 nM 5.31
CHEMBL5266050 IC50 = 4860.0 nM 5.31
CHEMBL5273409 IC50 = 4930.0 nM 5.31
CHEMBL5282167 IC50 = 4930.0 nM 5.31
CHEMBL5276607 IC50 = 18700.0 nM 4.73
CHEMBL23293 SALIRASIB IC50 = 48600.0 nM 4.31
CHEMBL29292 UBENIMEX IC50 > 500000.0 nM -
CHEMBL5275537 IC50 = 1.28 ug.mL-1 -
CHEMBL5270559 IC50 = 1.28 ug.mL-1 -
CHEMBL5273944 IC50 = 1.28 ug.mL-1 -
CHEMBL5283925 IC50 = 1.28 ug.mL-1 -
CHEMBL98 VORINOSTAT IC50 = 0.18 ug.mL-1 -