Assay Detail
Binding
CHEMBL5231289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PROTAC activity at TRIM24/VHL (unknown origin) assessed as degradation protein
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor/TRIM24 (CHEMBL5291690) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.74 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774575 | — | — | 1 | 8.10 |
| CHEMBL3775853 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774575 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3775853 | — | IC50 | = | 43.0 | nM | 7.37 |