Assay Detail
Binding
CHEMBL5231344
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Inhibition of Staphylococcus aureus ATCC 29213 FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (CHEMBL3994) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
FabI (enoyl acyl carrier protein reductase) - A potential broad spectrum therapeutic target and its inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.09 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178284 | — | — | 1 | 7.92 |
| CHEMBL525803 | CHLOROPEPTIN | — | 1 | 6.52 |
| CHEMBL5274978 | — | — | 1 | 6.47 |
| CHEMBL5276897 | — | — | 1 | 6.46 |
| CHEMBL5268393 | — | — | 1 | 6.30 |
| CHEMBL524665 | COMPLESTATINS A | — | 1 | 6.22 |
| CHEMBL510257 | VINAXANTHONE | — | 1 | 6.05 |
| CHEMBL463175 | CEPHALOCHROMIN | — | 1 | 5.72 |
| CHEMBL5278258 | — | — | 1 | 5.50 |
| CHEMBL1652621 | AFN-1252 | 2.0 | 1 | 5.02 |
| CHEMBL5283864 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178284 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL525803 | CHLOROPEPTIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5274978 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5276897 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5268393 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL524665 | COMPLESTATINS A | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL510257 | VINAXANTHONE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL463175 | CEPHALOCHROMIN | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5278258 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1652621 | AFN-1252 | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL5283864 | — | IC50 | = | 16000.0 | nM | 4.80 |