Assay Detail
Binding
CHEMBL5231493
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Inhibition of human MAO-B
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.05 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275768 | — | — | 1 | 8.47 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 8.36 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.15 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.22 |
| CHEMBL5288345 | — | — | 1 | - |
| CHEMBL5281072 | — | — | 1 | - |
| CHEMBL5275637 | — | — | 1 | - |
| CHEMBL5270573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275768 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL887 | RASAGILINE | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL972 | SELEGILINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5288345 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5281072 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5275637 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5270573 | — | IC50 | < | 100.0 | nM | - |