Assay Detail

CHEMBL5231852

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against SARS-COV-2 infected in African green monkey Vero E6 cells

ChEMBL ↗

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Target

SARS-CoV-2 (CHEMBL4303835) ↗

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Primary target SARS-CoV-2

CHEMBL4303835

Anchored from Assay target.

Protein identity SARS-CoV-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome coronavirus 2
Cell Type	Vero E6
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV-2 (CHEMBL4303835) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome coronavirus 2

Publication

COVID-19 therapy: What weapons do we bring into battle?

de Almeida SMV, Santos Soares JC, Dos Santos KL, Alves JEF, Ribeiro AG, Jacob ÍTT, da Silva Ferreira CJ, Dos Santos JC, de Oliveira JF, de Carvalho Junior LB, de Lima MDCA.
Bioorg Med Chem (2020) 28 : 115757 -115757
PubMed 32992245 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	5.54	5.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL46286	OMACETAXINE MEPESUCCINATE	4.0	1	5.68
CHEMBL1214598	UMIFENOVIR	3.0	1	5.39

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL46286	OMACETAXINE MEPESUCCINATE	EC50	=	2100.0	nM	5.68
CHEMBL1214598	UMIFENOVIR	EC50	=	4110.0	nM	5.39