Assay Detail
Functional
CHEMBL5231908
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Antiproliferative activity against human MCF7 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective Estrogen Receptor Degraders (SERDs): A Promising Strategy for Estrogen Receptor Positive Endocrine-Resistant Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.95 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5283812 | — | — | 1 | 9.89 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 9.46 |
| CHEMBL5278904 | — | — | 1 | 8.72 |
| CHEMBL5268670 | — | — | 1 | 8.62 |
| CHEMBL5280976 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5283812 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL5278904 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5268670 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5280976 | — | IC50 | = | 9.2 | nM | 8.04 |