Assay Detail

CHEMBL5231911

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiproliferative activity against human MCF7 cells assessed as reduction in cell proliferation

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Selective Estrogen Receptor Degraders (SERDs): A Promising Strategy for Estrogen Receptor Positive Endocrine-Resistant Breast Cancer.

Lu Y, Liu W.
J Med Chem (2020) 63 : 15094 -15114
PubMed 33138369 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.38	8.38

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4297509	ELACESTRANT	4.0	1	8.38

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4297509	ELACESTRANT	IC50	=	4.2	nM	8.38