Assay Detail
Functional
CHEMBL5232218
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Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitors of Eukaryotic Translational Machinery as Therapeutic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.57 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451930 | PLITIDEPSIN | 4.0 | 1 | 9.30 |
| CHEMBL414042 | — | — | 1 | 8.70 |
| CHEMBL499943 | DIDEMNIN A | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451930 | PLITIDEPSIN | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL414042 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL499943 | DIDEMNIN A | IC50 | = | 20.0 | nM | 7.70 |