Assay Detail
Binding
CHEMBL5232268
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MMP-3 (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.93 | 9.14 |
| Ki | 1 | 10.52 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 10.52 |
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 9.14 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.85 |
| CHEMBL76222 | REBIMASTAT | 2.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL279786 | BATIMASTAT | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL76222 | REBIMASTAT | IC50 | = | 157.0 | nM | 6.80 |