Assay Detail
Binding
CHEMBL5232284
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Competitive inhibition of human MMP-2 assessed as inhibition constant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.44 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063274 | — | — | 1 | 8.22 |
| CHEMBL483857 | — | — | 1 | 7.85 |
| CHEMBL1651842 | — | — | 1 | 7.64 |
| CHEMBL1834422 | — | — | 1 | 7.62 |
| CHEMBL1651847 | — | — | 1 | 7.05 |
| CHEMBL1834420 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063274 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL483857 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1651842 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1834422 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1651847 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL1834420 | — | Ki | = | 520.0 | nM | 6.28 |