Assay Detail
Binding
CHEMBL5232304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Heat shock protein HSP 90-beta/Hsp90 co-chaperone Cdc37 (CHEMBL4296081) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.39 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782984 | — | — | 1 | 5.77 |
| CHEMBL1170915 | — | — | 1 | 5.62 |
| CHEMBL4789502 | — | — | 1 | 5.54 |
| CHEMBL4758598 | — | — | 1 | 5.21 |
| CHEMBL4751648 | — | — | 1 | 5.17 |
| CHEMBL4763181 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782984 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1170915 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4789502 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4758598 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4751648 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4763181 | — | IC50 | = | 10000.0 | nM | 5.00 |