Assay Detail
Functional
CHEMBL5232305
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Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.86 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088297 | — | — | 1 | 6.10 |
| CHEMBL4782984 | — | — | 1 | 6.10 |
| CHEMBL4751648 | — | — | 1 | 6.00 |
| CHEMBL4752202 | — | — | 1 | 6.00 |
| CHEMBL4789502 | — | — | 1 | 6.00 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 5.96 |
| CHEMBL1172284 | — | — | 1 | 5.96 |
| CHEMBL4758598 | — | — | 1 | 5.96 |
| CHEMBL4763181 | — | — | 1 | 5.96 |
| CHEMBL4076720 | — | — | 1 | 5.89 |
| CHEMBL1170915 | — | — | 1 | 5.89 |
| CHEMBL4791763 | — | — | 1 | 5.80 |
| CHEMBL3417313 | — | — | 1 | 5.77 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.75 |
| CHEMBL4749841 | — | — | 1 | 5.38 |
| CHEMBL4762467 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088297 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4782984 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4751648 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4752202 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4789502 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1172284 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4758598 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4763181 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4076720 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1170915 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4791763 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3417313 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL301982 | CELASTROL | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4749841 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4762467 | — | IC50 | = | 6300.0 | nM | 5.20 |