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Assay Detail

CHEMBL5232532

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Recent contributions of quinolines to antimalarial and anticancer drug discovery research.
Van de Walle T, Cools L, Mangelinckx S, D'hooghe M.
Eur J Med Chem (2021) 226 : 113865 -113865
PubMed 34655985 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.00 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL471432 1 7.72
CHEMBL76 CHLOROQUINE 4.0 1 7.67
CHEMBL5275743 1 7.50
CHEMBL5274287 1 7.41
CHEMBL4777661 1 7.41
CHEMBL5272909 1 7.41
CHEMBL5275652 1 7.41
CHEMBL5269049 1 7.10
CHEMBL5274289 1 7.10
CHEMBL5290580 1 7.10
CHEMBL5283588 1 7.10
CHEMBL5279554 1 7.10
CHEMBL5289093 1 6.42
CHEMBL5271344 1 6.42
CHEMBL5273047 1 5.62
CHEMBL4740256 1 5.54
CHEMBL5290099 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL471432 IC50 = 18.95 nM 7.72
CHEMBL76 CHLOROQUINE IC50 = 21.55 nM 7.67
CHEMBL5275743 IC50 = 32.0 nM 7.50
CHEMBL5274287 IC50 = 38.75 nM 7.41
CHEMBL4777661 IC50 = 38.75 nM 7.41
CHEMBL5272909 IC50 = 38.75 nM 7.41
CHEMBL5275652 IC50 = 38.75 nM 7.41
CHEMBL5269049 IC50 = 79.0 nM 7.10
CHEMBL5274289 IC50 = 79.0 nM 7.10
CHEMBL5290580 IC50 = 79.0 nM 7.10
CHEMBL5283588 IC50 = 79.0 nM 7.10
CHEMBL5279554 IC50 = 79.0 nM 7.10
CHEMBL5289093 IC50 = 380.0 nM 6.42
CHEMBL5271344 IC50 = 380.0 nM 6.42
CHEMBL5273047 IC50 = 2420.0 nM 5.62
CHEMBL4740256 IC50 = 2900.0 nM 5.54
CHEMBL5290099 IC50 = 0.423 ug.mL-1 -