Assay Detail
Binding
CHEMBL5232751
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Inhibition of human DHFR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemotherapeutics for <i>Toxoplasma gondii</i>: Molecular Biotargets, Binding Modes, and Structure-Activity Relationship Investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.34 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 9.38 |
| CHEMBL32113 | — | — | 1 | 7.58 |
| CHEMBL32708 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL32113 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL32708 | — | IC50 | = | 8500.0 | nM | 5.07 |