Assay Detail
Binding
CHEMBL5232752
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Inhibition of Toxoplasma gondii DHFR
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemotherapeutics for <i>Toxoplasma gondii</i>: Molecular Biotargets, Binding Modes, and Structure-Activity Relationship Investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.91 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.85 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.85 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.77 |
| CHEMBL32708 | — | — | 1 | 7.55 |
| CHEMBL32113 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL32708 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL32113 | — | IC50 | = | 29.0 | nM | 7.54 |