Assay Detail
Functional
CHEMBL5232792
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Antiparasitic activity against Toxoplasma gondii infected in HFF cells assessed as parasitic growth inhibition incubated for 24 hrs by MTS/PMS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Toxoplasma gondii |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemotherapeutics for <i>Toxoplasma gondii</i>: Molecular Biotargets, Binding Modes, and Structure-Activity Relationship Investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.24 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88430 | — | — | 1 | 7.70 |
| CHEMBL292009 | BUPARVAQUONE | 2.0 | 1 | 7.00 |
| CHEMBL585431 | — | — | 1 | 6.72 |
| CHEMBL611070 | — | — | 1 | 5.97 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.44 |
| CHEMBL439 | SULFADIAZINE | 4.0 | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88430 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL292009 | BUPARVAQUONE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL585431 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL611070 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL439 | SULFADIAZINE | IC50 | = | 26050.0 | nM | 4.58 |