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Assay Detail

CHEMBL5233655

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Modification of 7-piperazinylquinolone antibacterials to promising anticancer lead compounds: Synthesis and in vitro studies.
Ahadi H, Emami S.
Eur J Med Chem (2020) 187 : 111970 -111970
PubMed 31881454 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 7.15 7.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4636122 1 7.15
CHEMBL4633435 1 7.15
CHEMBL4647394 1 7.15
CHEMBL4647558 1 7.15
CHEMBL4649384 1 7.15
CHEMBL4640038 1 7.15
CHEMBL4640200 1 7.15
CHEMBL4632631 1 7.15
CHEMBL4638094 1 7.15
CHEMBL4637492 1 7.15
CHEMBL4634909 1 7.15
CHEMBL4636149 1 7.15
CHEMBL4633427 1 7.15
CHEMBL4639575 1 7.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4636122 IC50 = 71.0 nM 7.15
CHEMBL4633435 IC50 = 71.0 nM 7.15
CHEMBL4647394 IC50 = 71.0 nM 7.15
CHEMBL4647558 IC50 = 71.0 nM 7.15
CHEMBL4649384 IC50 = 71.0 nM 7.15
CHEMBL4640038 IC50 = 71.0 nM 7.15
CHEMBL4640200 IC50 = 71.0 nM 7.15
CHEMBL4632631 IC50 = 71.0 nM 7.15
CHEMBL4638094 IC50 = 71.0 nM 7.15
CHEMBL4637492 IC50 = 71.0 nM 7.15
CHEMBL4634909 IC50 = 71.0 nM 7.15
CHEMBL4636149 IC50 = 71.0 nM 7.15
CHEMBL4633427 IC50 = 71.0 nM 7.15
CHEMBL4639575 IC50 = 71.0 nM 7.15