Assay Detail
Binding
CHEMBL5234085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human USP7 using human N-terminal GST-tagged UBA52 as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by coomassie brilliant blue staining-based SDS-PAGE analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 7 (CHEMBL2157850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.72 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.16 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.90 |
| CHEMBL5271414 | — | — | 1 | 4.68 |
| CHEMBL391533 | COROSOLIC ACID | — | 1 | 4.64 |
| CHEMBL5272735 | — | — | 1 | 4.48 |
| CHEMBL486400 | HEDERAGENIN | — | 1 | 4.47 |
| CHEMBL5275686 | — | — | 1 | - |
| CHEMBL260673 | METHYL URSOLATE | — | 1 | - |
| CHEMBL410525 | O-ACETYLURSOLIC ACID | — | 1 | - |
| CHEMBL404313 | ASIATIC ACID | — | 1 | - |
| CHEMBL481854 | MADECASSIC ACID | — | 1 | - |
| CHEMBL1797308 | — | — | 1 | - |
| CHEMBL5280627 | — | — | 1 | - |
| CHEMBL5282608 | — | — | 1 | - |
| CHEMBL5270544 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL5271414 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL391533 | COROSOLIC ACID | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL5272735 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL486400 | HEDERAGENIN | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL5275686 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL260673 | METHYL URSOLATE | IC50 | > | 50000.0 | nM | - |
| CHEMBL410525 | O-ACETYLURSOLIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL404313 | ASIATIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL481854 | MADECASSIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL1797308 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5280627 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5282608 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5270544 | — | IC50 | > | 50000.0 | nM | - |