Assay Detail

CHEMBL5234232

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Functional

Antimalarial activity against Plasmodium falciparum 3D7

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review.

Qin HL, Zhang ZW, Lekkala R, Alsulami H, Rakesh KP.
Eur J Med Chem (2020) 193 : 112215 -112215
PubMed 32179331 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.73	7.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL76	CHLOROQUINE	4.0	1	7.22
CHEMBL340244	CALYTHROPSIN	—	1	6.23

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL76	CHLOROQUINE	IC50	=	60.0	nM	7.22
CHEMBL340244	CALYTHROPSIN	IC50	=	590.0	nM	6.23