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Assay Detail

CHEMBL5234263

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MMP-3 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Stromelysin-1 (CHEMBL283)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview.
Mondal S, Adhikari N, Banerjee S, Amin SA, Jha T.
Eur J Med Chem (2020) 194 : 112260 -112260
PubMed 32224379 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 7.90 8.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL437017 1 8.51
CHEMBL427616 1 8.20
CHEMBL267178 1 7.89
CHEMBL34206 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL437017 IC50 = 3.1 nM 8.51
CHEMBL427616 IC50 = 6.3 nM 8.20
CHEMBL267178 IC50 = 13.0 nM 7.89
CHEMBL34206 IC50 = 100.0 nM 7.00