Assay Detail
Binding
CHEMBL5234352
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Inhibition of Mycobacterium tuberculosis DHFR
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydrofolate reductase (CHEMBL6065) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Dihydrofolate reductase inhibitors for use as antimicrobial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.21 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279457 | — | — | 1 | 9.02 |
| CHEMBL586115 | — | — | 1 | 7.65 |
| CHEMBL3828485 | — | — | 1 | 6.75 |
| CHEMBL3828771 | — | — | 1 | 6.34 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 4.96 |
| CHEMBL3616528 | — | — | 1 | 4.41 |
| CHEMBL336718 | — | — | 1 | 4.31 |
| CHEMBL4436643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279457 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL586115 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL3828485 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL3828771 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 10910.0 | nM | 4.96 |
| CHEMBL3616528 | — | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL336718 | — | IC50 | = | 49100.0 | nM | 4.31 |
| CHEMBL4436643 | — | IC50 | > | 24640.0 | nM | - |