Assay Detail
Binding
CHEMBL5234415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCT1 (unknown origin) assessed as reduction in [14C]lactate uptake incubated for 20 mins by liquid scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.70 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582422 | — | — | 1 | 8.10 |
| CHEMBL3582419 | — | — | 1 | 8.05 |
| CHEMBL3582420 | — | — | 1 | 7.96 |
| CHEMBL3582501 | — | — | 1 | 7.60 |
| CHEMBL3582421 | — | — | 1 | 7.47 |
| CHEMBL3892299 | — | — | 1 | 7.43 |
| CHEMBL3582500 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582422 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3582419 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3582420 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3582501 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3582421 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3892299 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3582500 | — | IC50 | = | 48.0 | nM | 7.32 |