Assay Detail
Binding
CHEMBL5235121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-fused human SHP1 (205 to 597 residues) using DiFMUP as substrate incubated for 30 mins by fluorescence based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal chemistry strategies for the development of protein tyrosine phosphatase SHP2 inhibitors and PROTAC degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.45 | 6.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472004 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472004 | — | IC50 | = | 355.0 | nM | 6.45 |