Assay Detail
Binding
CHEMBL5235145
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Inhibition of human IDO1 expressed in Escherichia coli using L-tryptophan as substrate incubated for 30 mins by methylene blue dye based microplate reader analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diverse chemical space of indoleamine-2,3-dioxygenase 1 (Ido1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.01 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5271416 | — | — | 1 | 7.00 |
| CHEMBL3746040 | — | — | 1 | 6.62 |
| CHEMBL4542547 | — | — | 1 | 6.30 |
| CHEMBL2385347 | — | — | 1 | 6.00 |
| CHEMBL2385355 | — | — | 1 | 6.00 |
| CHEMBL5284428 | — | — | 1 | 5.14 |
| CHEMBL78321 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5271416 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3746040 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4542547 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2385347 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2385355 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5284428 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL78321 | — | IC50 | = | 10000.0 | nM | 5.00 |