Assay Detail
Binding
CHEMBL5235422
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Displacement of [3H]-spiperone from human D4 receptor expressed in CHO cells assessed as inhibition constant
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent findings leading to the discovery of selective dopamine D<sub>4</sub> receptor ligands for the treatment of widespread diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.86 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2207643 | — | — | 1 | 9.40 |
| CHEMBL5285358 | — | — | 1 | 9.30 |
| CHEMBL140099 | — | — | 1 | 9.28 |
| CHEMBL5272162 | — | — | 1 | 9.18 |
| CHEMBL5278853 | — | — | 1 | 9.12 |
| CHEMBL143761 | — | — | 1 | 9.00 |
| CHEMBL160626 | — | — | 1 | 8.82 |
| CHEMBL5280364 | — | — | 1 | 8.82 |
| CHEMBL104035 | — | — | 1 | 8.70 |
| CHEMBL310843 | — | — | 1 | 8.66 |
| CHEMBL108122 | — | — | 1 | 8.55 |
| CHEMBL7927 | FAUC 113 | — | 1 | 8.51 |
| CHEMBL346389 | — | — | 1 | 8.37 |
| CHEMBL1616116 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2207643 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL5285358 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL140099 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL5272162 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL5278853 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL143761 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL160626 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL5280364 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL104035 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL310843 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL108122 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL7927 | FAUC 113 | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL346389 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL1616116 | — | Ki | = | 5.2 | nM | 8.28 |